What do studies show?
Studies using commercially available LIPUS devices have shown that, on average, fresh fractures will heal 38% faster than fractures that have not been treated with ultrasound.
This is dependent on the type and location of the fracture. LIPUS has proven to heal non-union fractures by 86%.
Acceleration of fracture healing
Pilla et al, Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit. The Journal of Orthopaedic Trauma, Vol 4, No 3, 1990: pp 246-253
Results: Ultrasound treated bone as strong in torsion as intact fibulae, increased periosteal reaction
Results Technical Specifications of LIPUS Device: f = 1.5 MHz | tp = 200 μs | REF = 1 KHz | le = 30 mW/cm²
Rate of healing of bone defect
Walsh et al, Effect of Low Intensity Pulsed Ultrasound on Healing of an Ulna Defect Filled with a Bone Graft Substitute. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 86B, 2008: pp 74–81
Results: LIPUS resulted in more new bone growth at wk 4 and 12 compared to control and increased VEGF expression
Results Technical Specifications of LIPUS Device: f = 1.5 ± 5% MHz | tp = 200 ± 10% μs | REF = 1 ± 10% KHz | le = 30 ± 30% mW/cm²
Effect of LIPUS on rate of fracture healing
Siska et al, External adjuncts to enhance fracture healing: What is the role of ultrasound? Injury Journal. 2008 Oct.39 (10): pp 1095-1105
Results: Safe, practical and effective treatment
Results Technical Specifications of LIPUS Device: f = 1.5 MHz | tp = 200 μs | REF = 1 KHz | le = 30 mW/cm²
Time to fracture healing
Busse et al, The effect of low-intensity pulsed ultrasound therapy on time to fracture healing: a meta-analysis. CMAJ. 2002 Feb 19;166(4): pp 437- 441
Results: LIPUS may significantly reduce the time to fracture healing for fractures treated non operatively
Results Technical Specifications of LIPUS Device: f = 1.5 ± 5% MHz | tp = 200 ± 10% μs | REF = 1 ± 10% KHz | le = 30 ± 30% mW/cm²
More Downloads
Animal Studies
–EFFECT-OF-TRANSOSSEOUS-APPLICATION-OF-LOW-INTENSITY-ULTRASOUND-AT-THE-TENDON-GRAFT-BONE-INTERFACE-HEALING–Effects-of-Low-Level-Laser-Therapy-and-Orthodontic-Tooth-Movement-on-Dental-Pulps-in-Rats
–LIPUS-Actuates-and-Increases-Cell-to-Cell-Communication-and-Connexin-43-Expression
–Improved-Cartilage-Repair-After-Stephen-Cook
–LIPUS-enhances-fracture-healing-at-critical-angles
–Low-Intensity-Pulsed-Ultrasound-May-Accelerate-Physeal-Closure-in-Rabbit-Growth-Plate-Damage-Repaired-by
–LOW-INTENSITY-PULSED-ULTRASOUND-PRODUCED-AN-INCREASE
–Low-Intensity-Pulsed-Ultrasound-Treatment-on-Spinal-Fusion-Augmented-with-Tissue-Engineered-Biomaterial-Composite
–Low-Intensity-Pulsed-Ultrasound-Accelerates-Rat-Femoral-Fracture-Healing-by-Acting-on-the-Various-Cellular-Reactions-in-the-Fracture-Callus
–Low-Intensity-Pulsed-Ultrasound-Stimulates-Intramedullary-Bone-Formation-and-Homing-of-Circulating-Connective
–Low-Intensity-Pulsed-Ultrasound-Stimulation-of-Condylar-Growth-in-Rats
–Low-Intensity-Transosseous-Ultrasound-Accelerates-Osteotomy-Healing-in-a-Sheep-Fracture-by-Hantes
–Low-Magnitude-High-Frequency-Mechanical-Signals-Accelerate
–Low-Level-Accelerations-Applied-in-the-Absence-of-Weight-Bearing-Can-Enhance-Trabecular-Bone-Formation
–Low-Magnitude-High-Frequency-Vibration-Accelerates-Callus-Formation-Mineralization-and-Fracture-Healing-in-Rats
–Low-Magnitude-High-Frequency-Vibration-Accelerates-Callus-Formation
–Non-invasive-low-intensity-pulsed-ultrasound-accelerates-bone-healing-in-the-rabbit
–Osteogenic-Differentiation-of-Rat-Bone-Marrow-Stromal-Cells-by-Various-Intensities-of-Pulsed-Ultrasound
–Small-Oscillatory-Accelerations-Independent-of-Matrix-Deformations-Increase-Osteoblast-Activity-and-Enhance-Bone-Morphology
–teijin-presentation
–THE-EFFECT-OF-VARIABLE-WAVEFORM-LOW-INTENSITY-PULSED
–The-Effects-of-Low-Intensity-Pulsed-Ultrasound-on-Tendon-Bone-Healing-in-a-Transosseous-Equivalent-Sheep
–The-Stimulation-of-Bone-Growth-by-Ultrasound
LIPUS Articles (Studies)
–USING-LOW-INTENSITY-PULSED-ULTRASOUND-TO-IMPROVE-MUSCLE–A-multi-center-randomized-clinical-study-to-compare-the-effect
–BMC-Musculoskelet-Disord-delayed-unions
–Comparison-of-Low-Intensity-Pulsed-Ultrasound-and-Pulsed-Electromagnetic
–Effects-of-Low-Level-Laser-Therapy
–External-adjuncts-to-enhance-fracture-healing
–Identification-of-genes-responsive-to-low-intensity
–Improved-healing-response-in-delayed
–LOW-INTENSITY-PULSED-ULTRASOUND-PRODUCED-AN-INCREASE-1.pdf
–Low-intensity-pulsed-ultrasound-LIPUS-in-fresh
–LOW-INTENSITY-PULSED-ULTRASOUND-EFFECTS-ON-NONUNIONS
–Low-intensity-pulsed-ultrasound-affects-RUNX2
–Low-intensity-pulsed-ultrasound-for-bone-healing
–LOW-INTENSITY-PULSED-ULTRASOUND-FOR-THE-TREATMENT-OF
–Low-Intensity-Pulsed-Ultrasound-Stimulation-of-Condylar-Growth-in-Rats-1
–Low-intensity-pulsed-ultrasound-increases-bone-volume
–MODELLING-THE-PROPAGATION-OF-ULTRASOUND-IN-THE-JOINT-SPACE
–PROLONGED-ENDOCHONDRAL-BONE-HEALING-IN-SENESCENCE
–Short-term-efficacy-of-physical-interventions-in-osteoarthritic-knee
–The-biology-of-fracture-healing
–THE-EFFECT-OF-VARIABLE-WAVEFORM-LOW-INTENSITY-PULSED-1
–The-effects-of-LIPUS-on-soft-tissue-healing
Osteoporosis Studies
–In-vivo-Effects-of-Low-Intensity-Ultrasound-Stimulation-for-Prevention-of-Osteoporotic-Bone-Fracture–Effect-of-Low-Intensity-Ultrasound-Stimulation-on-Bone-Strength-Improvement-for-Prevention-of-a-Risk-of
Studies Reviews
–The-Use-of-LowIntensity-Ultrasound-to-Accelerate-the-Healing-of-Fractures-Rubin–D__Sound-Healing_pdfprotected_13a
–Enhanced-Bone-Regeneration-with-Ultrasound_Claes_Pbiomolbio_2007
–External-adjuncts-to-enhance-fracture-healing
–How-does-pulsed-Low-Intensity-Ultrasound-enhance-fracture-healing-Haim-Stein
–JMCM-Supplement-Article-Optimizing-Outcomes-with-Fresh-and-Nonunion-Fractures
–LIPUS-Accelerates-Healing-Fractures_Rubin_JBJS_2001
–LIPUS-Fracture-Healing_Mundi_Manuscript_2009
–Low-intensity-pulsed-ultrasonography-for-fractures-systematic-review-of-randomised-controlled-trials
–Low-Intensity-Ultrasound-effects-on-NonUnions-Dieter-Gebauer
–Low-Intensity-Pulsed-Ultrasound-and-Pulsed-Electromagnetic-Field-in-the-Treatment-of-Tibial-Fractures
–LOW-INTENSITY-PULSED-ULTRASOUND-EFFECTS-ON-NONUNIONS
–Low-intensity-pulsed-ultrasound-for-bone-healing
–Low-intensity-Pulsed-Ultrasound-for-bone-healing_v2
–LOW-INTENSITY-PULSED-ULTRASOUND-FOR-THE-TREATMENT-OF
–The-biology-of-fracture-healing
–The-effect-of-low-intensity-pulsed-ultrasound-therapy-on-time-to-fracture
–The-effects-of-LIPUS-on-soft-tissue-healing
–The-enhancement-of-bone-regeneration-by-ultrasound